Scale & Pressure
- Test scale 1–200 mL, pilot scale 100–8000 mL, production scale 2–100 L.
- Operating pressure 150–6,000 psi, model dependent.
- Online versions for continuous operation; hand-driven and jacketed versions also available.
Liposome Extruder
Genizer Online High Pressure Liposome Extruder
Online High Pressure Liposome Extruder — 150 to 6,000 psi, 1 mL to 100 L scales, 316L stainless steel
Genizer Online High Pressure Liposome Extruder from Genizer is a scalable extrusion system for homogeneous unilamellar liposomes and lipopolyplexes, from test scale (1–200 mL) up to production scale (2–100 L).
Manufactured by
Genizer
Genizer Online High Pressure Liposome Extruder
Review the confirmed product information, including description, features, benefits, and applications.
The Genizer High Pressure Liposome Extruder produces unilamellar liposome and lipopolyplex populations by controlled extrusion of multilamellar liposome suspensions. The formulation is repeatedly forced through polycarbonate membranes with defined pore sizes, giving homogeneous liposome sizes typically in the 50–120 nm range.
Configurations cover test scale (1–200 mL), pilot scale (100–8000 mL) and production scale (2–100 L). Depending on the model, the extruder operates from 150 psi up to 6,000 psi, using hand-driven, compressed-air-driven or pump-driven (online) power systems.
It is made of 316L stainless steel with pharmaceutical-grade materials and electropolished, passivated internal surfaces for sanitary operation. Tri-Clamp, NPT, UNF, flange and custom connections allow integration into laboratory and GMP manufacturing, and the design is compatible with FDA and GMP requirements for sterile processing.
Extrusion & Sizing
- Track-etched polycarbonate membrane extrusion.
- Homogeneous liposome sizes, typically 50–120 nm.
- Jacketed versions available for temperature control.
Construction & Connections
- Constructed from 316L stainless steel.
- Electropolished and passivated internal surfaces.
- Connection options: Tri-Clamp, NPT, UNF, flange, custom.
- Optional pressure gauge and pressure/temperature transducers.
Uniform Size Distribution
Uniform and reproducible liposome and lipopolyplex size distribution.
Lab to Production
Scalable from laboratory to full production volumes.
Flexible Operation Modes
Operation modes can be matched to process requirements.
Low Contamination Risk
The sanitary design reduces contamination risk.
GMP Integration
Integrates easily into existing sterile and GMP processes.
Batch or Continuous
Suitable for both batch and continuous manufacturing.
The extruder is used for liposome work from laboratory testing to commercial manufacturing.
Formulation and Testing
Liposome formulation, lipopolyplex preparation, pharmaceutical R&D and laboratory testing.
Sterile Filtration Studies
Sterile filtration studies on liposomal formulations.
Pilot-Scale Validation
Pilot-scale validation of liposome processes.
Commercial Liposome Manufacturing
Commercial manufacturing of liposomes.
Pharmaceutical-Grade Materials
The extruder uses pharmaceutical-grade materials.
FDA & GMP Approvable
The extruder has an FDA & GMP approvable design.
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