Membranes & Sizing
- Track-etched polycarbonate nano-membranes (19 mm).
- Membrane pore size options from 30 nm to 30 μm.
- Typical liposome size of 50–120 nm within 5–10 passes.
Liposome Extruder
Genizer HandExtruder Liposome Extruder
HandExtruder — hand-driven, up to 700 psi, 19 mm membranes, 30 nm to 30 μm pores, 316L stainless steel
Genizer HandExtruder Liposome Extruder from Genizer is a hand-driven high-pressure extruder for producing homogeneous unilamellar liposomes and lipopolyplexes at lab and pilot scale, typically sized 50–120 nm.
Manufactured by
Genizer
Genizer HandExtruder Liposome Extruder
Review the confirmed product information, including description, features, benefits, and applications.
The Genizer High Pressure Hand Driven Liposome Extruder (HandExtruder) is a manually powered extrusion system for producing homogeneous, unilamellar liposome and lipopolyplex populations from multilamellar liposome suspensions.
The sample is passed back and forth between two gas-tight syringes through track-etched polycarbonate membranes with defined pore sizes, giving controlled size reduction and uniform liposome size typically in the 50–120 nm range. Homogeneous samples are typically reached within 5–10 extrusion passes, with minimal dead volume.
The unit is made of 316L stainless steel with pharmaceutical-grade materials, is easy to clean and fully autoclavable, and is compatible with GMP and FDA requirements. Variants with thermo-jacket cooling (RT version) are available for heat-sensitive lipids or lipids with high phase transition temperatures.
Operating Limits
- Manual hand-driven operation with two gas-tight syringes.
- Maximum operating pressure: 700 psi.
- Maximum operating temperature: 80°C (176°F).
- Thermo-jacket cooling variant (RT version) available.
Construction & Cleaning
- Constructed from 316L stainless steel.
- Virtually zero dead volume.
- Easy disassembly, flushing and cleaning.
- Fully autoclavable.
- GMP and FDA approvable materials.
Uniform Liposome Size
Produces highly uniform and reproducible liposome sizes.
Small Sample Volumes
Fast processing with a minimum sample volume of 0.25 mL.
Simple, Cost-Effective Use
Simple and cost-effective operation.
Heat-Sensitive Lipids
Suitable for heat-sensitive and high-transition-temperature lipids.
Low Contamination Risk
The sanitary design keeps contamination risk low.
Development to Early Scale
Fits formulation development and early-scale manufacturing.
The HandExtruder is used for liposome and lipopolyplex work from R&D to pilot scale.
Liposome Formulation
Liposome formulation and lipid-based drug delivery systems.
Lipopolyplex Preparation
Preparation of lipopolyplexes from multilamellar suspensions.
Pharmaceutical R&D
Pharmaceutical R&D and sterile filtration studies.
Laboratory and Pilot Production
Laboratory and pilot-scale production.
GMP and FDA Approvable
The extruder has a GMP and FDA approvable design.
Need support with this liposome extruder?
Share your lipid composition, sample volume, target particle size and processing temperature, and our Pharma & FMCGs team will support you with the suitable product information.
Other Products in R&D Solutions
Explore other products available within the same product category and open each page for complete technical details.
Merck Cogent Lab TFF System
Modular lab-scale TFF system for concentration and diafiltration, with 500 mL, 2 L or 5 L tanks.
Genizer MixGenizer High Pressure Micromix Homogenizer
Multi-inlet micromix homogenizer up to 30,000 psi and 100 mL/min with ±0.1 mL inlet volume control.
Genizer NanoGenizer-Dual Homogenizer
Portable dual-pump lab homogenizer up to 30,000 psi, with 180 mL/min at 25,000 psi and 120 mL/min at 30,000 psi.
Genizer NanoGenizer-II High Pressure Homogenizer
Electric bench-top homogenizer up to 45,000 psi for lipid nanoparticles, 150 mL/min at 30,000 psi.
Genizer NanoMixer Microfluidic Mixers
Benchtop microfluidic mixers in dual, triplex and quad versions for mRNA and lipid nanoparticles, up to 500 psi.
Genizer Jacketed Liposome Extruder
Jacketed membrane extruder that keeps lipids above transition temperature for uniform liposome size reduction.
Genizer Online High Pressure Liposome Extruder
Scalable 316L liposome extruder from 150 to 6,000 psi, covering 1 mL test scale up to 100 L production.
SPM TDP Single Punch Tablet Press
Compact single punch tablet press with adjustable fill depth, tablets up to 25mm (TDP-6).